National Center for Tuberculosis and Lung Disease (NCTBLD)
Tbilisi, Georgia, is a head facility for TB control in Georgia, which
creates, implements and administers the National Tuberculosis Program.
The Program’s aim is to decrease spreading of Tuberculosis in Georgia.
The main activities of the Center includes: i. Administration of National Tuberculosis Program, ii. Provision of high quality TB diagnosis, iii. Treatment of TB patients, iv. Prevention of Tuberculosis, v. biomedical research.
The following types of services can be obtained in the Center:
ii.Treatment - Conservative and Surgical
iii.Examination and prevention of TB patients’ family members
The National Center for TB and Lung Diseases consists of:
The following laboratories are
operating at NCTBLD: i. National Reference Laboratory (NRL) serves as a
reference biosurveillance laboratory for whole region and provides
opportunity for high quality biomedical research at national and
International level. ii. General microbiology. iii. Immunology. iv.
Biochemistry v. Cytology and pathomorphology. vi. Molecular biology,
vii. Clinical laboratory.
- Four inpatient departments
- Department for Thoracic surgery
- Extrapulmonary TB department
- Children's department
- X-ray service
NCTBLD laboratory is equipped with technologies, including:
The NCTBLD is in the process of implementation of RFLP assay.
- Cell culture laboratory
- PCR technologies
- ELISA assay
The NCTBLD possesses the mycobacterium culture collection.
The staff of the NCTBLD consists of highly skilled professionals: physicians, surgeons, laboratory workers, scientists.
The NCTBLD is actively collaborating with:
WHO - World Health Organization;
GFATM - Global Fund against AIDS, TB and Malaria
USAID/MSCI - Madical Service Corporation International
GOPA/KFW – German Governement
ICRC - International Committee of Red Cross
MSF - Medecins Sans Frontieres
KNCV - KNCV Tuberculosis Foundation, Netherlands
National Center is in close contacts with other countries in the region
(Azerbaijan, Armenia) and has a potential of conducting joint, multi
CRDF - Civillian Research and Development Fund
Completed and ongoing projects at NCTBLD:
||Clinical and Molecular epidemiology of TB in the Republic of Georgia
||Clinical and Molecular epidemiology of drug-resistant TB in Georgia
||Clinical and Molecular epidemiology of drug-resistant TB in Georgia and the Caucasus
|| Multiple-Drug Resistant Tuberculosis: Epidemiologic, Diagnostic, and Therapeutic Research Opportunities
||Development of multiple drug resistant tuberculosis (MDRTB) surveillance and National TB program(NTP) evaluations republic of Armenia and Georgia
||Determination of susceptibility to some second-line drug of Mycobacterium tuberculosis strains isolated in the Republic of Georgia
||Characterization of M.tuberculosis gene expression patterns during growth in the human lung
||Monitoring chemotherapy regimen efficacy by Mycobacterium tuberculosis mRNA detecting in sputum specimens
||Role of Hepatitis C virus as a risk factor for Anti-tuberculosis drug induced hepatotoxicity
||Prevalence and Risk Factors for Extensively Drug Resistant TB (XDR-TB): A Population Based Study
||National Institutes of Health/Fogarty International Center
||Prevalence and Risk factors for latent Tuberculosis infections among health care workers in Georgia
|| National Institutes of Health/Fogarty International Center
||Prevalence and risk factors for extensively drug resistant tuberculosis (XDR TB) and evaluation of the GenoType MTBDRplus assay for rifampin and isoniazid susceptibility rapid testing in a population based study in Tbilisi, country of Georgia
||Emory Global Health Institute/CRDF
||Impact of Vitamin D Supplementation on Host Immunity to Mycobacterium tuberculosis and Response to Treatment: Building Translational Research Capacity in Nutrition and Infectious Diseases in the Republic of Georgia
||Emory Global Health institute
|Selection of appropriate treatment and infection control measures by integrated high throughput genotyping and drug resistance determination of M.tuberculosis clinical isolates
Collaborative Research Interests of NCRLD with NIH/NIAID
1. Genotyping of MDR and XDR MTB cultures isolated in Georgia.
2. Extrapulmonary tuberculosis.
4. HIV - co-infection.
5. Polyclonal TB.
6. Study general bacterial pool of cavity in cavitary TB cases.
7. Elaboration and implementation of rapid and effective diagnostic tools in pediatric TB. Differential diagnosis of TB meningitis in children and study of mixed pulmonary/extrapulmonary TB cases.
8. Study of TB drug-resistance dynamics in new and retreatment cases.
9. Study of resistance to so-called 3rd line drugs.
10. Study of human genetic markers during TB disease.
12. Create a new form of anti-tuberculosis drugs (ATD) complex on the basis of nanoparticles produced from the new type of biodegradable polymers, calculated at a specific phase of the standard treatment regimen for single-introducing it into the body of the patient and the subsequent controlled drug releasing in order to reduce the side effects of medicines .
13. TB phages- Development of isolation and application methods for Treatment and Prevention of Drug-Resistant Tuberculosis
14. Investigation of Electrochemical Lysis application opportunities for use in resistant tuberculosis treatment
15. Monitoring of M.bovis and M.avium paratuberculosis in cattle and poultry.